LDL cholesterol level: the difference between LDL and LDL cholesterol level; Is LDL-cholesterol truly ‘bad’ cholesterol? Is HDL-cholesterol protective? An in depth look at LDL cholesterol level and its physiological significance.

Get the 7 day Cholesterol-lowering program here: thecholesterolchallenge.com (use code 50%OFF for half price)

LDL cholesterol level under 100mg/dL. LDL vs LDL-cholesterol, cholesterol is NOT the problem, HDL is NOT good cholesterol and LDL is not ‘bad’. lipoproteins carry fat. lipoproteins: low density lipoprotein or LDL vs high-density lipoprotein or HDL. lab results: LDL-cholesterol level, not LDL. lipoproteins (LDL) carry cholesterol. LDL-cholesterol is cholesterol carried in LDL lipoproteins. LDL lipoproteins = cars. LDL-cholesterol = passengers

HDL-cholesterol = cholesterol traveling in HDL lipoproteins. add all cholesterol = Total cholesterol (lab results)

Triglycerides in lipoproteins. LDL vs LDL-cholesterol level. good cholesterol and bad cholesterol? is LDL-cholesterol ‘bad’? animals with high LDL-cholesterol level, people with high LDL-cholesterol level = heart disease. people with low LDL-cholesterol level are health freaks?

RCTs on LDL-cholesterol level: group with LDL-cholesterol level lowered has less heart disease. high LDL-cholesterol level is a problem. strong case that high LDL-cholesterol level is an issue

we have different levels of LDL-cholesterol. low ldl-cholesterol level from birth = less heart disease. ldl-cholesterol level not 100% in genes

high LDL-cholesterol level spells trouble. “no longer an ‘LDL-Cholesterol hypothesis’. increased LDL-Cholesterol level causal; lowering LDL particles reduces events”. “cholesterol-containing lipoproteins, particularly LDL cause CHD”

does high LDL-cholesterol level cause heart disease? main problem are lipoproteins, not LDL-cholesterol. “number of lipoprotein particles rather than cholesterol or triglycerides”
Heart disease caused by lipoproteins stuck in artery wall. lab results: LDL-cholesterol, triglycerides. apoB (carried by LDL) tells us number of lipoproteins

LDL-P (particles) = count of LDL lipoproteins. LDL lipoproteins = cause of heart disease. lab results: cholesterol… Is LDL-cholesterol level useless? for most people, more lipoproteins = more cholesterol, LDL-Cholesterol level = ok estimation

non-HDL cholesterol (Total cholesterol – HDL-cholesterol) = cholesterol not carried by HDL lipoproteins. if LDL-cholesterol level is good, chances are LDL particles are ok. lipoproteins carry cholesterol. too many lipoproteins cause heart disease, esp. LDL. LDL-Cholesterol gives idea of LDL lipoproteins
is HDL good? high HDL-cholesterol = less heart disease. hence good cholesterol. BUT raising HDL-cholesterol or genetically high HDL-cholesterol isn’t better
“simplistic hypothesis for HDL-cholesterol: increasing levels reduces CV events”. HDL not useless. HDL lipoproteins pull cholesterol from plaque. raising HDL-Cholesterol? people ask “how do I get my HDL higher” (they mean hdl-cholesterol, on lab results)
very high HDL-cholesterol level associated with higher risk? high LDL-Cholesterol + HDL-Cholesterol? is HDL-Cholesterol “bad”? good vs bad cholesterol doesn’t match evidence. LDL isn’t “bad”. We all have LDL and LDL-cholesterol. LDL-cholesterol like other parameters

for details on lowering cholesterol: thecholesterolchallenge.com (cholesterol-lowering menu)
video on lowering cholesterol with healthy foods. next video we’ll keep looking at cholesterol

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References:
https://www.ahajournals.org/doi/10.1161/01.ATV.20.4.1068
https://academic.oup.com/eurheartj/article/38/32/2459/3745109
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz962/5735221
https://academic.oup.com/eurheartj/article/41/1/111/5556353
https://www.nejm.org/doi/full/10.1056/nejmoa054013
https://bit.ly/2NiK5vQ
https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003062&type=printable />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103514/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070150/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889017/
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.312617
https://www.sciencedirect.com/science/article/pii/S0140673612603122

Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author’s knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
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