Metabolism and Transport of LDL Cholesterol – This is the video on Metabolism of LDL, Transport of LDL, Functions of LDL cholesterol and Clinical Application of LDL along with NEET PG MCQs.
Introduction to LDL Cholesterol – 00:24 minutes
Metabolism of LDL and LDL Receptors – 00:59 minutes
Functions of LDL Cholesterol – 03:06 minutes
Clinical Applications of LDL Cholesterol – 04:17 minutes
NEET PG MCQs – 06:26 minutes
Low density lipoproteins (LDL) transports cholesterol from liver to peripheral tissues.
The only apoprotein present in LDL is apo-B-100.
Most of the LDL particles are derived from VLDL.
The half-life of LDL in blood is about 2 days.
The LDL is taken up by peripheral tissues by receptor mediated endocytosis.
LDL receptors are present on all cells but most abundant in hepatic cells.
LDL receptors are located in specialized regions called clathrin-coated pits.
Binding of LDL to the receptor is by apo-B-100.
When the apo-B-100 binds to the apo-B-100 receptor, the receptor-LDL complex is internalized by endocytosis.
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